Anti-Alzheimer's disease

(-)-Huperzine A
Catalog No: CFN99958

(-)-Huperzine A is a naturally occurring potent reversible AChE inhibitor that penetrates the blood-brain barrier, it also has several neuroprotective effects including modification of beta-amyloid peptide, reduction of oxidative stress, anti-inflammatory, anti-apoptotic and induction and regulation of nerve growth factor.

Reserpine
Catalog No: CFN98112

Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans, it can significantly delay paralysis and increase the longevity in this model.

Butanol
Catalog No: CFN98128

Tyrosol is a potential hypo-pigmenting agent, it has neuroprotective, antioxidant, anti-hyperglycemia, and anti-allergic inflammatory effects. Tyrosol has cytoprotective effect in I/R-caused myocyte mortality was involved with the mitigation of ROS, prohibition of the activation of ERK, JNK and caspase-8, and elevation of Hsp70 and Bcl-2/Bax ratio.Tyrosol is a quorum-sensing molecule in Candida albicans, it has important implications on the dynamics of growth and morphogenesis in Candida.

Crebanine
Catalog No: CFN98275

Crebanine has antiarrhythmic, anticancer, anti-inflammatory, and analgesic properties; it can significantly improve the cognitive deficits induced by scopolamine, via the alpha-7 nicotinic acetylcholine receptor, crebanine or its scaffold can be used as the starting point to develop a drug for Alzheimer's disease.Crebanine can reduce TNF-α-induced cancer cell proliferation, invasion, and survival by suppressing NF-κB activity and expression profile of its downstream genes.

8-Deoxygartanin
Catalog No: CFN98427

8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced β-amyloid (Aβ) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD. 8-Deoxygartanin has antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. 8-Deoxygartanin has cytotoxic effect on human melanoma cells, it inhibits p65 activation with IC50 values of 11.3 microM, it is a potential candidate as anti-melanoma agents.